We have worked hard to compile every past paper by topic and exam board! 3.8 (ii): The linkage of genes on a chromosome and sex linkage * Understand the uses and implications of genetic screening and prenatal testing Biology A level Course plan This plan shows the structure of the course and gives an outline of the contents. 0000020127 00000 n t�y�����V&+�WXx��e����"ˮƸ�)��&G#c • Answer all questions. Edexcel GCE Biology Advanced Subsidiary Unit 1: Lifestyle, Transport, Genes and Health Tuesday 21 May 2013 – Afternoon Time: 1 hour 30 minutes 6BI01/01R You do not need any other materials. )�A���^U~bta �y��烒,�J$��a�"rI�a�� �4>��j������l�؊���'���/@� �� (2) 0000018017 00000 n Sat this today and i found it really solid haha! H��VKn1����R�Dq�EE^� E? Tes Global Ltd is Edexcel GCSE. A level. 2.7: Understand the nature of the genetic code Cystic Fibrosis. 6.10: Understand how one gene can give rise to more than one protein through posttranscriptional changes to messenger RNA (mRNA). DNA, RNA, Genetics and Inheritance (Edexcel Int. Cystic fibrosis 1 (a) The x-ray image on the left shows how cystic fibrosis can affect the … Cause: The inheritance of two recessive alleles for cystic fibrosis. The following specification points are covered by the lessons within this bundle: * The involvement of ATP and carrier proteins in active transport, endocytosis and exocytosis 0000018997 00000 n 0000035776 00000 n Salters Nuffield Advanced Biology (Edexcel Specification A) is a course designed to approach key biological concepts and skills by placing them within a real life context. (a) Cystic fibrosis results from the expression of inherited gene mutations. 0000001902 00000 n ���wئ ��������݇�����H��FL���)@���G$P�K�5�8��[�@ɲF���1e�k�/xh��>��۹/��! * Simple and facilitated diffusion as methods of passive transport A good command of biological terminology can mean the difference between a poor grade and an excellent one! 0000026593 00000 n 0000032699 00000 n (i) Someone with cystic fibrosis will have a (1) A heterozygous genotype B homozygous genotype C heterozygous phenotype D homozygous phenotype 0000025972 00000 n Edexcel GCSE biology paper 1 Unofficial mark scheme A-level OCR Biology Paper 1,2 and 3 Revision and Study Chat Over 1000 A-Level Biology Exam Questions Aqa a-level biology 7402 - paper 2 - unofficial mark scheme 13th June 2019 This * Structure and properties of cell membranes (1)..... *(b) Explain how a child can have cystic fibrosis when neither of the parents has this disorder. Factsheets, Articles, PowerPoints, Revision Notes and Practice Questions for Pearson (Edexcel) A Level Biology (A): Topic 2: Genes and Health Email info@curriculum-press.co.uk Phone … Cystic fibrosis AS Edexcel Biology Xavier DANIEL, Ph.D. Cystic fibrosis = Mucoviscidosis Genetic disorder Due to mutation in a gene Several different possible mutations in the same gene Affected organs Lungs Pancreas Liver Kidneys Intestines From Greek kystis ”bladder, pouch” Fiber Greek osis = disease A level Edexcel Biology Unit 1 21st May 2013? 1) Caused by mutation in the gene that codes for CFTR protein ( Cystic Fibrosis Transmembrane Conductance Regulator) 2) CFTR is a carrier protein which transports chloride ions out of cells and into mucus – causes water to move into the water by osmosis which makes it watery 3) Mutant CFTR is much less efficient at transporting chloride ions out of the cell, so less water moves out by osmosis – makes … 0000033279 00000 n 0000027938 00000 n This lesson bundle contains 16 lessons which have been designed to cover the Pearson Edexcel A-level Biology A (Salters Nuffield) specification points which focus on the structure of DNA and RNA, their roles in replication and protein synthesis, and genetics and inheritance. * Patterns of inheritance, in the context of monohybrid inheritance 105 0 obj <>stream 0000033403 00000 n 6 Cystic fibrosis is a genetic disorder that can affect many body systems, including the respiratory system. Covered in Unit 2 Section 3.2.1; CFTR is a plasma membrane protein. 0000035422 00000 n (Since of course you get marks awarded for using the correct technical language in the right context when answering exam questions). BiologyGuide.app > HBIO1 > Cystic Fibrosis. 0000027703 00000 n On Stuvia you will find the most extensive lecture summaries written by your fellow students. All genetic conditions are called disorders and those that inherit them are called sufferers. Biological Molecules . 2 *P48541A0220* DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA DO NOT WRITE IN THIS AREA Answer ALL questions Some questions must be answered with a cross in a box . NEC are offering structured Fast Track A levels in the following subjects: Biology; Chemistry; Maths; Physics; The flexible nature of distance learning and home study courses means that it’s possible to do this, as long as you’re able to schedule in enough study time. 0000000016 00000 n 2.14: Understand how the expression of a gene mutation in people with cystic fibrosis impairs the functioning of the gaseous exchange, digestive and reproductive systems (1 mark) b. 8. A bundle is a package of resources grouped together to teach a particular topic, or a series of lessons, in one place. * The formation of polypeptides and proteins How many people would you expect to have the disease in a population of 100,000? The Edexcel GCSE in Biology is designed for use in school and colleges. Although the majority of the lesson is described with reference to the gaseous exchange system, the impaired functioning of the digestive system in terms of the blockage of the pancreas and liver secretions is considered and discussed and the students are challenged on their understanding through a range of exam-style questions. * The properties of gas exchange surfaces in living organisms registered in England (Company No 02017289) with its registered office at 26 Red Lion Again, the students are guided through the events that lead to the depletion of the apical surface liquid and the cilia being unable to move the viscous mucus. * The process of protein synthesis 8. * A gene is a sequence of bases on DNA that codes for the amino acid sequence of a polypeptide (Total for question 1= 6) Q2 Cystic fibrosis is a genetic disease caused by mutations in the CFTR gene. endstream endobj 60 0 obj <> endobj 61 0 obj <<>> endobj 62 0 obj <>/ExtGState<>/Font<>/ProcSet[/PDF/Text]>>/Rotate 0/TrimBox[0 0 595.02 841.98]/Type/Page>> endobj 63 0 obj [/Separation/Black/DeviceCMYK 98 0 R] endobj 64 0 obj <> endobj 65 0 obj <> endobj 66 0 obj <>stream This lesson describes how the expression of a gene mutation impairs the functioning of the gaseous and digestive systems in people with cystic fibrosis. 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